MaskNGly

01 Detect N-X-S/T02 Score influence03 Compare homologs

AccessionCanonical UniProtKB accessions, 6–10 characters

Private research deployment · sequences are cached by content hash

Cached result

P0DOX5Homo sapiens449 aa

Immunoglobulin gamma-1 heavy chain

Candidate N-glycosylation sequons mapped into structural context. Select a marker or evidence row to synchronize the analysis.

View UniProt record

Interactive structure

Sites mapped in three dimensions

AlphaFold DB v691.62mean pLDDT

Positioning the structure…

Detected sequons

2 candidate sites

High signal

N299

Normalized influence meets the 0.5 operating threshold.

0.8840–1

Sequence context294–306

REEQYNSTYRVVS

N299NST+2 residue 301

UniProt experimental evidenceECO:0000269

N-linked (GlcNAc...) (complex) asparagine

PubMed 19358553 PubMed 29449492

UniProt manual assertion based on published experimental evidence.

ESM perturbation

Residue influence profile

Values are min–max normalized across the full sequence before cropping this window. C_N masks N at i = 299; C_S/T masks S/T at i+2 = 301.

EvidenceESM-2 · layer 33 · single-mask perturbation · Normalized influencePipeline esm2-mask-n-st-v2. Structure predictions and influence scores are research evidence, not clinical interpretation.

Evolutionary motif comparison

Is the sequon conserved across homologs?

Sequence similarity and motif alignment are kept separate from expression-level omics evidence.

96.4%selected identity

queryP0DOX5Homo sapiens

287motif N299313

Conserved N-X-S/T motifCurated demonstration neighborhood · production analyses use the configured homology index